Best SARMs for bulking (Selective Androgen Receptor Modulators) have emerged as a promising pharmaceutical alternative to anabolic steroids for medical use.
The primary goal of scientists in developing SARMs was to mimic the muscle-building benefits of steroids without triggering the associated androgenic side effects. This objective has been realized through the principle of tissue selectivity, as SARMs selectively bind to cells responsible for muscle growth while avoiding those that could cause androgen-related side effects like hair loss, acne, and prostate enlargement.
SARMs are favored for their triple-action benefits: enhancing muscle mass, increasing muscular strength, and aiding in fat reduction.
In this discussion, we will evaluate the top SARMs for bulking, ranking them from the most to the least effective.
Note: The term “SARMs” is sometimes loosely applied to performance-enhancing drugs (PEDs) that differ structurally but are included here due to their similar effects.
1. RAD 140 (Testolone)
RAD 140 has been demonstrated to significantly boost lean muscle growth, greatly augment muscular strength, and facilitate fat loss.
Users often report gains of up to 15 pounds of lean muscle mass while concurrently decreasing their body fat percentage by 3%.
Enhancements in major compound lift performance can reach up to 30%. For instance, a person deadlifting 300 pounds could potentially see their lift increase to nearly 400 pounds after a cycle of RAD 140.
Recommended dosages of RAD 140 usually span from 10–20 mg/day for men over a period of 6–12 weeks. Women typically use a lower range of 5–10 mg per day for a similar timeframe.
RAD 140 Results
A noted case revealed a user’s lean body mass increased by 6.2kg (13.7 lbs) and body fat decreased by 2.8% after 7 weeks of taking 10 mg/day of RAD 140. Apart from increased perspiration, no significant side effects were observed.
The individual also recorded a weight increase of around 20% on his primary compound lifts, which includes squats, bench press, and deadlifts.
Such outcomes suggest that even at modest doses, RAD 140 can deliver impressive results.
RAD 140 Side Effects
RAD 140 has a favorable safety profile, which is why it is often considered the top SARM for bulking. While other SARMs like S23 or YK-11 may compete with RAD 140’s bulking capabilities, they tend to have more pronounced side effects.
Though not excessively harsh or toxic, RAD 140 can nonetheless lead to certain side effects.
Liver function tests indicate that RAD 140 can cause an elevation in liver enzymes, specifically ALT and AST, indicative of hepatic strain. To mitigate this, a daily intake of 500 mg of TUDCA (tauroursodeoxycholic acid) may be employed for its liver protective qualities, due to its high water solubility and ability to neutralize acidic bile salts.
Additionally, RAD 140 has the potential to decrease HDL (high-density lipoprotein) cholesterol levels, marginally raising the risk of atherosclerosis. This is a side effect of many orally administered SARMs, which can activate hepatic lipase, an enzyme that reduces HDL levels. Adequate HDL is beneficial for prevention of arterial plaque buildup.
To manage any increases in blood pressure, patients are often advised to incorporate 4 grams of fish oil daily and include regular cardiovascular exercise in their routines.
Since RAD 140 can suppress endogenous testosterone production, a post-cycle therapy (PCT) is recommended to hasten the restoration of natural testosterone levels.
An anecdote from our practice includes a patient who ingested 17 mg/day of RAD 140 for 3 months and showed a significant decline in total testosterone, from 750 ng/dL down to 193 ng/dL. Nonetheless, such instances of hypogonadism are generally temporary, with normal testosterone levels typically resuming after several weeks.
2. LGD-4033 (Ligandrol)
LGD-4033 might be deemed the best SARM for those focused on bulking, especially for its propensity to aid in weight gain.
While RAD 140 is associated with lean muscle development, LGD-4033 tends to produce more notable overall mass gains, in part due to increased water retention.
This additional fluid is primarily caused by LGD-4033’s influence on the body’s natural aromatization process (the conversion of testosterone into estrogen).
The lean muscle gains from LGD-4033 are comparable to those achieved with RAD 140, but this is more apparent once the post-cycle shedding of excess water occurs. Approximately 20–30% of weight gained during a cycle of LGD-4033 may be water weight.
It’s common to see users putting on around 20 lbs with LGD-4033, where about 5 lbs could be attributed to water retention.
Some athletes prefer the fuller physique that LGD-4033 provides, while others opt for the more defined and vascular look that comes with RAD 140 usage.
Typical dosages for LGD-4033 are up to 6 mg/day for an 8-week cycle.
LGD-4033 Effects
An individual administered a substantial 10 mg daily dose of LGD-4033 over a period of 12 weeks and observed a considerable gain of roughly 20 pounds of lean muscle mass. Additionally, they reported a marked decrease in subdermal fat, as indicated by the enhanced muscle contours visible in subsequent images.
Such a dosage and period of 10 mg/day for 12 weeks represent a robust cycle for LGD-4033. The individual mentioned endured no significant adverse effects aside from a minor escalation in acne occurrences. Notably, post-cycle therapy (PCT) was not employed, given the absence of symptoms associated with reduced testosterone levels.
Potential Adverse Effects of LGD-4033
We note that side effects from LGD-4033 tend to be more intense than those arisen from RAD 140.
There is a marginal increase in the incidence of puffy nipples among LGD-4033 users due to elevated aromatase activity, although this side effect remains rare, especially in contrast to highly estrogenic steroids like Dianabol or Anadrol.
A substantial LGD-4033 intake can suppress testosterone to hypogonadal levels, necessitating strong PCT protocols to rejuvenate the HPTA (hypothalamic-pituitary-testicular axis). For recovery, we recommend two reliable SERMs, Nolvadex at a dose of 20-40 mg daily and Clomid at 50-100 mg daily, for a duration of 30 days to accelerate endogenous testosterone restoration.
LGD-4033 holds the potential to elevate blood pressure, primarily through a decline in HDL and rise in LDL cholesterol levels. In one instance, researchers recorded a 40% plummet in HDL levels with a mere 1 mg daily dose of LGD-4033 over just three weeks (1). Nevertheless, cholesterol levels normalized after 56 days. Hence, the conclusion was that LGD-4033 is “safe” and “well tolerated.”
Research indicates little to no alteration in liver enzyme levels (serum aminotransferases) when LGD-4033 is ingested in minimal doses (2). Yet, hepatocellular liver damage is a possibility with high dosages of LGD-4033, pre-existing liver conditions, or concurrent use of other hepatotoxic drugs (3). A daily 500 mg TUDCA supplementation should help in controlling excessive ALT/AST surges.
3. Ostarine Analysis
Ostarine is recognized as a milder SARM, with its advantages significantly surpassing its downsides. It’s deemed efficacious for both muscle building and fat cutting.
Typically, a beginner’s first SARM cycle might be solely comprised of Ostarine, yielding up to 10 pounds of lean muscle gains alongside a 3% body fat reduction.
For novices, Ostarine is arguably the optimal choice for a bulking SARM, given their higher sensitivity to adverse effects. On the other hand, for the seasoned individuals, Ostarine is often favored during cutting phases to conserve muscle, enhance vascularity, and promote fat loss.
Even as a mild SARM, Ostarine has been seen to facilitate considerable strength enhancements, with newcomers often increasing their major compound lifts by 30–40 pounds.
Men typically consume Ostarine in a range of 10–30 mg daily for about 8 weeks, while women may take up to 10 mg daily spanning 4–8 weeks.
Outcomes from Ostarine
One user documented considerable muscle hypertrophy and significant fat reduction after taking 20 mg/day of Ostarine for a duration of 6 weeks.
This case exemplifies how body composition improvements can be substantial even if the scale reflects a modest weight change: the individual lost 7 pounds while still achieving muscle growth. Given that the compound exerts an anabolic and lipolytic effect, an individual’s weight might remain relatively constant despite considerable enhancements in body composition.
Note: Women’s muscle hypertrophy outcomes with Ostarine differ greatly from men’s, with women potentially gaining 20–25 pounds in lean mass. The more prominent anabolic response in females may be attributed to their naturally lower levels of testosterone.
Side Effects of Ostarine
While Ostarine boasts the most favorable safety profile among SARMs, it can still prompt moderate testosterone suppression. Some users don’t experience noticeable low testosterone signs, opting out of PCT. However, there have been instances of users experiencing 60–70% reductions in their total testosterone level, leading them to adopt at least one SERM post-cycle.
Ostarine might trigger a minor degree of hair loss in those with a predisposition for male-pattern baldness, due to its indirect increase in natural 5-alpha reductase enzyme levels, which boosts the conversion of testosterone to DHT (dihydrotestosterone). Another potential side effect is acne vulgaris, occurring in users who genetically produce an excess of sebum.
Similar to other SARMs, Ostarine usage can lead to elevated enzyme levels of ALT and AST, as well as modifications in HDL and LDL cholesterol levels, albeit to a reduced extent. Preventive measures such as TUDCA and fish oil supplementation may be considered to mitigate these side effects.
4. YK-11 Profile
YK-11 does not classify as a SARM; rather, it acts as a myostatin inhibitor. Myostatin is a protein also known as a myokine, and it inhibits the process of muscle development. Therefore, individuals with higher levels of myostatin typically have a reduced capacity for muscle growth.
Unlike traditional Selective Androgen Receptor Modulators (SARMs) that promote muscle growth by targeting androgen receptors, YK-11 facilitates muscle anabolism through a different mechanism. This distinct action makes YK-11 a prime candidate for stacking with SARMs, allowing users to simultaneously initiate two anabolic hormonal pathways, thus potentially enhancing muscle-building results.
Studies have indicated that individuals who naturally possess lower levels of myostatin can achieve muscle mass that is double that of the average person—with a considerable increase in strength as well (4).
YK-11 has been observed to promote the development of lean muscle mass without causing water retention or bloating, positioning it as a suitable SARM for those aiming to preserve a defined and shredded physique.
YK-11 Results
One individual experienced a weight increase of 15 pounds over a 6-week regime of YK-11. The dosing schedule was 10 mg/day for the initial three weeks, escalating to 15 mg/day for the latter half of the cycle, weeks four to six.
During this cycle, the user also observed a significant reduction in subcutaneous fat, leading to enhanced muscle definition.
YK-11 Side Effects
While YK-11’s capabilities in muscle hypertrophy and strength amplification are competitive with top-tier SARMs, it falls to the fourth position due to its severe side effects.
YK-11 is known to manifest side effects similar to those experienced with traditional SARMs but at a heightened degree.
The side effects of YK-11 have been compared to those caused by Trenbolone, especially regarding mood alterations. Users often report increased irritability, aggression, anger, and feelings of paranoia.
Additionally, as a ‘dry’ compound, YK-11 can exert diuretic effects, potentially leading to joint discomfort due to reduced fluid lubrication. This may pose a particular concern for individuals who engage in heavy lifting with low repetitions, as they may be more prone to joint soreness.
A significant concern arising from the use of YK-11 is its substantial suppressive nature. Although YK-11 is a myostatin inhibitor and not a standard SARM, our Sex Hormone Binding Globulin (SHBG) test results indicate notable harm to the Hypothalamic-Pituitary-Testicular Axis (HPTA). Post-use, patients commonly describe symptoms associated with low testosterone levels, including fatigue, decreased overall well-being, and lower libido.
In cases where YK-11 induces severe suppression, a potent post-cycle therapy protocol is recommended, following the guidance devised by Dr. Grant Fourie, to restore natural testosterone levels:
- hCG: 2000 IU every other day (administered for a 20-day period)
- Tamoxifen (Nolvadex): 20mg administered twice daily (administered for a 45-day period)
- Clomiphene (Clomid): 50mg administered twice daily (administered for a 30-day period)
Furthermore, there is a risk of experiencing acne vulgaris and male pattern baldness due to YK-11 indirectly increasing 5 alpha-reductase levels, which can raise sebum and DHT (dihydrotestosterone) production. However, the manifestation of acne or hair loss primarily depends on an individual’s genetic predisposition.
YK-11 usage can also impact cholesterol levels and liver enzymes ALT/AST (5), with users seeing varying degrees of change based on genetic and lifestyle factors.
5. S23
S23 is currently acknowledged as the most potent and toxic SARM available. It could be considered the superior SARM for bulking based on its positive effects, yet due to the severe side effects, it is ranked fifth.
The impact of S23 is reminiscent of the anabolic steroid Winstrol (Stanozolol), which is known for its fat-reducing and substantial lean muscle and strength-building properties, without promoting water retention.
Both compounds, S23 and Winstrol, are known for hepatotoxicity and cardiotoxicity (6), making them appropriate only for those with extensive experience in the use of SARMs or steroids.
Typically, men consume 10–30 mg/day of S23 across cycles lasting 8–10 weeks.
S23 Results
An example here is of a user who administered 32 mg/day of S23 for 10 weeks and gained an approximate 20 pounds of muscle while also reducing his body fat percentage.
S23 Side Effects
S23 has been associated with mood-related side effects, including irritability and a predisposition to anger, as well as lethargy or depressive symptoms, suggesting a potential intolerance to this compound.
Moreover, S23 demonstrates extreme suppressive effects on testosterone production, resulting in post-cycle testosterone levels that may drop to hypogonadal ranges (below 300 ng/dL).
An increase in liver enzyme levels and a decrease in HDL cholesterol are also expected with the use of S23, thereby, raising the temporary risk of atherosclerosis or cholestasis.
Conclusion of the best sarms for bulking
In evaluating the benefits and drawbacks of the discussed SARMs, RAD 140 and LGD-4033 emerge as top choices.
Nevertheless, for those new to muscle-building routines, Ostarine is recommended as a gentle introduction.
Ostarine provides beginners with the opportunity to gradually acclimate to the effects of SARMs, preparing them for more powerful options like RAD 140 later on.
While S23 and YK-11 are potent anabolic agents, they require cautious use due to their strong suppression and potential toxicity.
REFERENCES
(1) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4111291/
(2) https://pubmed.ncbi.nlm.nih.gov/22459616/
(3) https://aasldpubs.onlinelibrary.wiley.com/doi/full/10.1002/hep4.1456
(5) https://www.sciencedirect.com/science/article/pii/S0006291X21000668
Dr. Grant Fourie, a specialist in male hormones, is based in Cape Town, South Africa. He provides comprehensive treatments for conditions related to low testosterone, such as erectile dysfunction, fatigue, and mood changes. His methods include hormone replacement therapy and other modern treatment options.
Contact me via email or phone to book personal appointment in my clinic: The Village Square, Cape Town - South Africa