Achieve Incredible Results: The Top 5 Anadrol Cycles for Massive Gains

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Discover the expert insights on the top 5 Anadrol cycles for significant muscle gains and peak performance. Learn from a professional how to optimize your Anadrol regimen safely and effectively. Get answers to your questions on cycle length, dosing, and managing side effects now.

Oxymetholone, commonly known as Anadrol, is a potent steroid utilized by weightlifters striving to amplify muscle mass (hypertrophy) and strength significantly.

The muscle-building capabilities of Anadrol are unparalleled, making it potent enough even to aid ectomorphs or “hard gainers” in achieving substantial muscle gains.

The only steroid that compares to Anadrol in terms of weight gain potential is Dianbol.

Anadrol is most effectively employed during the off-season for muscle building, and the cycles discussed herein are designed with mass gain in mind. Although it’s possible to use Anadrol for cutting, it’s less conventional due to the potential for water retention and bloating.

The Top 5 Anadrol Cycles for Massive Gains

Given its intense nature, Anadrol should be reserved for those with prior steroid experience, except when beginners opt for smaller doses. Beginners are advised to start with milder steroids such as testosterone in their initial cycles.

Top 6 Anadrol Cycles

The following cycles range from the least to most intense. As you progress down the list, expect an increase in severity of side effects. The bottom cycles are meant for those who are experienced with potent steroid cycles.

1. Anadrol-Only Cycle


Targeted for beginners, this cycle involves a conservative dosage.

If considerable side effects manifest at a daily dose of 50mg, it’s advisable not to increase the dose to 75mg at week 4 (continue with 50mg/day).

A 100mg daily dose is not recommended for the first cycle with Anadrol.

Even at a reduced dosage, significant gains in size and strength can occur, especially as the body has yet to acclimatize to this compound.

Beginners have reported gains of up to 30 lbs from this cycle.

Anadrol-Only Cycle (Advanced)


Intended for advanced users only.

For those with Anadrol experience, looking for greater dosages and extended cycle lengths for enhanced gains, this cycle may be suitable.

This regimen is for individuals in good health who undergo regular medical check-ups.

Undertaking this cycle with pre-existing health issues may lead to further health deterioration.

2. Anadrol and Deca Durabolin Cycle

WeekDeca DurabolinAnadrol

Anadrol may be stacked with the injectable steroid Deca Durabolin, promoting further muscle hypertrophy and strength increase.

Deca Durabolin is less harsh compared to Anadrol, which means side effects are not significantly exacerbated than when running Anadrol by itself. However, there will be a greater suppression of testosterone post-cycle, necessitating a robust post-cycle therapy (PCT).

After independent Anadrol cycles, this combination may be approached due to its relatively moderate dosages.

The primary side effects we observe with Deca Durabolin include reduced libido and erectile dysfunction, often referred to as ‘Deca dick,’ triggered by its effect on prolactin levels.

To mitigate these effects and maintain sexual function, we use Dostinex or Cabergoline to treat hyperprolactinemia — an overproduction of prolactin. We find Dostinex effective in quickly restoring sexual desire and erection quality (1).

Anadrol and Deca Cycle (Advanced)

WeekDeca DurabolinAnadrol

This cycle involves higher dosages and thus presents increased results along with heightened side effects.

3. Anadrol and Testosterone Cycle

Stacking Anadrol with Testosterone, another formidable bulking steroid, can lead to substantial muscle and strength enhancement. This combination is one of the most effective pairings for mass gain we’ve seen.


Testosterone is administered as an injectable steroid, meaning that liver strain is not significantly added to with the inclusion of Testosterone.

Nevertheless, compared to Anadrol alone, natural testosterone production will be more suppressed after the cycle, and the likelihood of experiencing gynecomastia (gyno), high blood pressure, acne, and hair loss may increase.

During the cycle, to prevent gyno, patients will commonly take a SERM (like Nolvadex) to mitigate increased estrogen levels in the breast tissue.

Anti-aromatase medications are not effective in this cycle for controlling high estrogen because, unlike testosterone, Anadrol does not aromatize but directly stimulates estrogen receptors.

4. Anadrol and Winstrol Cycle

Used for either bulking or cutting, this stack combines Anadrol with Winstrol, which aids in enhancing lean muscle gains, fat loss, and providing a ‘drier’ appearance.


This combination might appear odd since:

  • Winstrol is typically associated with cutting cycles.
  • Winstrol leads to a drier physique, while Anadrol is known for causing notable water retention.When Anadrol is used without a diet high in calories and sodium, the issue of water retention is trifling. Low intakes of calories and sodium have led some users to experience negligible water retention. Consequently, numerous competitors in men’s physique contests include Anadrol in their regimen before stepping on stage to enhance muscle fullness.

By managing your diet to limit fluid retention (either through low-calorie or low-sodium choices), your body can maintain a leaner appearance while still achieving substantial muscle growth.

The primary concern with employing this cycle is its considerable strain on the body.

Our liver function tests have demonstrated that both Winstrol and Anadrol are liver-toxic steroids. They also heavily suppress natural testosterone production and can adversely impact heart health, leading to high LDL and low HDL cholesterol levels.

From our perspective, considering the benefits versus the drawbacks, this is potentially one of the least favorable cycles for a bodybuilder. This is due to the limited advantages provided by Winstrol, which only serve to intensify Anadrol’s side effects.

Despite these issues, this cycle remains prevalent among bodybuilders who prefer oral steroids over injectables.

5. Anadrol and Dianabol Cycle

When combined in a single cycle, Anadrol and Dianabol make up two of the most potent steroids for bulking. This cycle is known to cause the most notable increases in both mass and volume. We’ve observed how dramatically this combination inflates user’s muscles, sometimes to the extent they are cautious about including supersets in their training.


After the cycle, bodybuilders might notice a decrease in size, which can be attributed to the loss of intracellular water retention.

Through our findings, this cycle ranks as one of the most liver-damaging, with both steroids being oral and c-17 alkylated. Hence, we advise against it if your liver isn’t in prime condition.

Nonetheless, some studies indicate that the effects of Anadrol on the liver may not be as severe as the bodybuilding community believes. Moreover, the liver has a notable capacity for recovery after being subjected to stress, unlike other organs. The critical factor with steroid use concerning the liver is to avoid prolonged cycles and to allow sufficient recovery time post-cycle.

Those interested in this cycle should consider supplementing with TUDCA at a dose of 500mg daily for no longer than three months. This has proven highly effective in minimizing liver damage.

It’s recommended to take TUDCA both during and after cycles to maximize liver protection. Additionally, it’s crucial to abstain from alcohol entirely.

This sample cycle employs conservative dosages with the consideration of potential liver strain and other risks.

Our patients have found that consistent cardiovascular exercise can help control significant increases in blood pressure, which should be monitored regularly throughout the cycle due to the inevitable occurrence of water retention and cholesterol fluctuations.

6. Anadrol, Trenbolone and Testosterone Cycle


The combination of these three steroids is likely to result in the most substantial gains ever experienced, yet it brings about severe side effects and should thus be used with extreme caution.

Rich Piana once mentioned that this was the greatest cycle he ever used.

The issues most commonly associated with this cycle include acute testosterone suppression, significant blood pressure spikes, risks of gynecomastia, and a notable chance of hair thinning or loss on the scalp. Liver toxicity will be a factor as well, although to a lesser extent than the Dianabol/Anadrol cycle due to the inclusion of injectable steroids like Testosterone and Trenbolone.

The combination of Anadrol and Trenbolone is another potent and popular cycle.

Female Anadrol Cycles

Research indicates that Anadrol is in fact one of the top steroids for women, particularly for those hoping to avoid virilization, contrary to popular belief that suggests women should not use Anadrol.

Clinical studies have shown that women taking large doses of Anadrol for extended periods do not experience masculinization. In one study, doses of 100–150 mg over 30 weeks resulted in no virilization among the female participants. Anecdotal evidence from our experience supports this finding.

A common misconception is that Anadrol’s severe side effects in men, some of which are androgenic, will also cause similar effects in women. However, practical experiences show otherwise.

This may be because Anadrol causes an increase in estrogen levels while not binding strongly to sex hormone-binding globulin (SHBG), which is known for causing virilizing effects when levels are high in women.Individuals might use Anadrol solo or pair it with Anavar to potentially augment muscle development and aid in fat reduction.

Anavar has a reputation for being a steroid that many women can use with a lower chance of developing masculine characteristics, especially during brief cycles.

Solo Anadrol Cycle for Women


For those opting for just Anadrol, the dosage is kept on the conservative side, even though some research points to the possibility of higher doses without an increased rate of masculinization.

Nevertheless, this modest dosing is often ample for noticeable enhancements in muscle strength and size. Also, the length of this cycle is relatively short when compared to the duration in certain studies.

Combined Anavar and Anadrol Cycle for Women


Women who have previously undergone cycles with Anavar or Anadrol independently and desire additional muscle growth can combine the two steroids.

For both steroids, lower doses are advised, and the combined cycle’s duration does not exceed six weeks. Experience shows that extending Anavar use beyond this period increases the likelihood of masculinization due to protracted cycles.

Administering Anadrol

Anadrol typically arrives in 50 mg tablets. To keep the levels of oxymetholone stable in your system, it is suggested to divide your dosage across the day rather than taking it all at once.

For those on a daily dose of 100mg, this could mean consuming two 50mg tablets.

If your daily dosage is 50mg, you could halve the tablets.

For daily dosages totaling 75mg, the preferred method is to take three 25mg tablets.

Note: It is best to take Anadrol on an empty stomach, as food—particularly fatty ones—can lessen its effectiveness due to the fat-soluble nature of this and many other anabolic steroids.

However, consuming Anadrol alongside grapefruit juice might increase its bioavailability. This is attributed to the inhibition of the CYP3A4 enzyme by grapefruit juice, which otherwise reduces the effectiveness of many medications, including anabolic steroids.

If you choose to combine Anadrol with grapefruit juice, exercise caution to avoid accidental overconsumption.

Post-Cycle Therapy

Following an Anadrol cycle, it’s common to engage in Post-Cycle Therapy (PCT) to hasten the revival of natural testosterone production.

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Without PCT, individuals may encounter a decline in overall well-being, sexual health, and the benefits from their cycle, but an effective PCT can help mitigate these effects.

The three PCT medications found to be efficacious include:

  • Clomid
  • Nolvadex
  • hCG

These can significantly elevate testosterone levels.

In cases of severe suppression, all three medications may be required simultaneously. Conversely, moderate Anadrol dosages may necessitate only one or two of these treatments.

Here is a robust PCT regimen based on accumulated experience:

  • Administer hCG every other day for 20 days, at 2000 IU per dose.
  • Take Nolvadex daily for 45 days, in 2 x 20mg doses.
  • Use Clomid daily for 30 days, at 2 x 50mg doses.

Anadrol Perspectives: Before and After

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The transformation featured here comes from a bodybuilder who went from natural (on the left) to using Anadrol (on the right). Pairing Anadrol with Deca Durabolin, he saw a remarkable increase in size and mass over several cycles.

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This sort of combination may contribute up to 40 pounds of mass, a number that could rise with the incorporation of additional steroids.

For those aiming for mass accumulation, Anadrol can be effective, even though it might not be ideal for keeping a lean waistline, especially while consuming a higher-calorie diet. Individuals with a higher body fat percentage may want to consider other steroids or cutting before taking Anadrol, which can lead to excessive bulkiness and water retention.

Taking Anadrol might also be better for cardiovascular health in lean individuals versus those who are overweight.

Frequently Asked Questions

Is Anadrol safe?

Anadrol (Oxymetholone) has been prescribed in the medical context for conditions like cachexia for extended periods. However, it is crucial to note that the dosages for these therapeutic purposes are considerably lower than those often used by bodybuilders. Even under medical supervision, potential risks and side effects can arise.

Consequently, Anadrol isn’t entirely risk-free when employed at the dosages commonly favored by bodybuilders. Yet, when taken for a short term by healthy individuals at lower to moderate doses, benefits may be observed with minimal harm, especially with concurrent liver and cholesterol support. Notably, the probability of long-term bodily harm grows with extended use of Anadrol and the number of cycles one undergoes.


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Individuals who embark on any Anadrol regimen can expect substantial enhancements in muscular strength and bulk. Known for its potent nature and potential for toxicity, Anadrol demands a prudent approach during use.

Novices are advised to refrain from using Anadrol until they have prior experience with testosterone.

Intermediate users may consider moderate dosages of Anadrol, while seasoned individuals might combine it with other potent agents, exercising due diligence.

The top five Anadrol combinations include:

  • Anadrol combined with Testosterone
  • Anadrol paired with Trenbolone
  • Anadrol and Winstrol stack
  • Anadrol in conjunction with Deca Durabolin
  • Anadrol mixed with Dianabol

Nonetheless, pairing Anadrol with any steroid tends to enhance outcomes compared to its solo use.

This guide does not exhaust all the possible pairings with oxymetholone; several other efficient substances like Anavar, a steroid often favored for cutting phases, can be used alongside Anadrol, though its oral form and subtler impact make it an atypical choice.

Inclusion of a post-cycle therapy is imperative for restoring mental and physical well-being.

It is critical to seek medical advice before starting any steroids or drugs mentioned in this discussion, and to undergo regular medical examinations.










General Practitioner at | Website | + posts

Dr. Grant Fourie, a specialist in male hormones, is based in Cape Town, South Africa. He provides comprehensive treatments for conditions related to low testosterone, such as erectile dysfunction, fatigue, and mood changes. His methods include hormone replacement therapy and other modern treatment options.
Contact me via email or phone to book personal appointment in my clinic: The Village Square, Cape Town - South Africa


About Dr. Grant Fourie

Dr. Grant Fourie, a specialist in male hormones, is based in Cape Town, South Africa. He provides comprehensive treatments for conditions related to low testosterone, such as erectile dysfunction, fatigue, and mood changes. His methods include hormone replacement therapy and other modern treatment options. Contact me via email or phone to book personal appointment in my clinic: The Village Square, Cape Town - South Africa

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