Trenbolone side effects, a highly sought-after anabolic steroid within the bodybuilding community, is prized for its exceptional ability to promote lean muscle growth while simultaneously aiding in fat loss, all without causing water retention.
Its versatility allows Trenbolone to be effectively used during both cutting and bulking cycles, making it one of the most aesthetically pleasing AAS available.
While it may not lead to significant overall weight gain, its capacity to increase lean muscle tissue is unmatched, rivaled only by Dianabol and Anadrol in our experience.
However, as with any powerful drug, along with notable benefits come equally significant drawbacks, and Trenbolone is no exception.
Trenbolone Acetate may be the most potent steroid for rapidly transforming a user’s physique, but we have observed it to also be among the most detrimental, both physiologically and psychologically.
It’s important to note that different esters of Trenbolone, such as Acetate and Enanthate, will produce the same side effects, but due to the varying length of esters and serum testosterone levels peaking at different speeds, the timing of side effects will occur at different stages.
For instance, some individuals may experience side effects very early into a cycle of Trenbolone Acetate, while it may take 1-2 weeks later to notice the same level of effects on Enanthate, owing to it being a longer ester.
9 Trenbolone Side Effects
1. Cholesterol & Blood Pressure
The most concerning side effect of Trenbolone that we observe is alterations in cholesterol levels, leading to increased cardiovascular strain and left ventricular hypertrophy.
We have seen regular use of Trenbolone, and other anabolic steroids, result in cardiomyopathy (heart disease). Hence, individuals with a genetic predisposition to cardiovascular issues should avoid Trenbolone.
While we do not recommend Trenbolone use, for those who choose to use it, we have found that regular cardiovascular exercises and a daily intake of 4g of fish oil can help decrease blood pressure and improve blood flow to and from the heart.
These measures will not completely reverse cardiovascular strain from Trenbolone, but they notably reduce the risk of atherosclerosis (hardening of the arteries).
Trenbolone should not be stacked with any oral steroids, such as Dianabol, Anadrol, or Winstrol, as they have devastating effects on cholesterol levels. Orals are particularly damaging to the heart, as they stimulate hepatic lipase in the liver, an enzyme responsible for decreasing HDL cholesterol (the healthy cholesterol that reduces plaque build-up).
2. Testosterone Suppression
All anabolic steroids will suppress natural testosterone production, as the administration of exogenous testosterone causes the body to cease endogenous production.
When individuals cycle steroids, their overall testosterone levels increase, but their natural testosterone levels plummet as the body detects excessive hormone levels.
This causes a transient effect that ultimately leads to a crash post-cycle when Trenbolone injections cease.
Due to the potent nature of Trenbolone, we often see users fully ‘shut down’ post-cycle, as Tren severely affects the HPTA. Consequently, natural testosterone levels can take several weeks or months to recover back to standard levels, the duration depending on the dosage taken, length of the cycle, and PCT protocol, which can help accelerate this recovery period.
During this transition period, while testosterone levels are shut down, our patients have experienced depression, erectile dysfunction, diminished libido, low energy levels, and decreased overall well-being.
3. Possible Gynecomastia
Despite not causing aromatization, which leads to the stimulation of estrogen receptors, some assume that Trenbolone cannot cause gynecomastia — this is not accurate.
Trenbolone significantly raises progesterone, which is also a female hormone responsible for regulating menstrual cycles in women. Elevated levels of progesterone in men can result in lactation, leading to puffy nipples and potentially gynecomastia.
We have observed that stacking Trenbolone with estrogenic steroids, such as Dianabol, Testosterone, or Anadrol, exacerbates this effect due to a greater dominance of female sex hormones and further negative feedback inhibition of testosterone.
Interestingly, we have found anti-estrogens to be effective at preventing the onset of progesterone-induced gynecomastia.
In terms of anti-estrogen options, bodybuilders can opt for AIs (aromatase inhibitors) or SERMs (selective estrogen receptor modulators).
AIs block the conversion of testosterone into estrogen, which can worsen cholesterol levels. However, SERMs work by directly inhibiting estrogen’s effects in the mammary glands without affecting aromatization.
The use of AI’s can negatively impact blood pressure by affecting estrogen levels and healthy cholesterol ratios. To prevent gynecomastia, Selective Estrogen Receptor Modulators (SERMs) are generally preferred over AI’s because they do not have a detrimental effect on blood lipids.
However, it’s important to note that popular SERMs like Nolvadex and Clomid should not be taken with Trenbolone, as they can elevate progesterone levels, potentially worsening tren-induced gynecomastia.
In case of puffy or swollen nipples, it may be suitable to have an AI ready. However, taking an AI before this stage is often unnecessary and can exacerbate the cardiovascular strain posed by Trenbolone.
Common AI options for bodybuilders are Letrozole (Femara) and Anastrozole (Arimidex).
4. Acne Vulgaris
Trenbolone’s high androgenic nature can lead to excess sebum production, causing oily skin and acne vulgaris. Some sensitive users may experience severe cystic acne, for which products like Accutane (Isotretinoin) have been effective in clearing up acne when used during the cycle. Research has shown that a daily dose of 20mg of Accutane is highly effective and safe for treating moderate to severe acne. It also offers long-term benefits by preventing future breakouts.
5. Male Pattern Baldness
Trenbolone’s high androgenic rating can contribute to hair loss due to elevated levels of Dihydrotestosterone (DHT), causing thinning and receding of the scalp. Long-term use of anabolic steroids, especially Trenbolone, can accelerate hair loss. While some individuals with strong genetics may not experience significant hair loss, the side effect is largely determined by genetics.
Some bodybuilders use 5-alpha-reductase inhibitors such as Finasteride to block the conversion of testosterone into DHT and reduce follicle damage on the scalp. However, reducing DHT levels may negatively impact muscle hypertrophy and strength gains during a cycle.
6. Visceral Fat
While many anabolic steroids burn subcutaneous fat, they can also increase visceral fat levels. High visceral fat levels can cause a bloated or protruding midsection, even in individuals with low subcutaneous body fat. Trenbolone users may experience more defined abdominal muscles at the expense of a potentially more bloated-looking stomach due to the hormone’s effects on body composition.
7. Anxiety/Depression
Trenbolone’s side effects are not solely physical, as patients commonly report feeling irritable, anxious, paranoid, and depressed. This may be due to Trenbolone’s stimulating effect on the central nervous system, resulting in an increase in adrenaline output and a shift into a state of fight or flight mode. This chemical alteration can lead individuals to perceive normal situations as threats, potentially causing panic attacks and bouts of depression. The reasons for Trenbolone’s more notable stimulating effect compared to other anabolic steroids are unclear. This has led some bodybuilders to avoid this steroid for optimal mental well-being.
To mitigate the impact of high adrenaline levels when using Trenbolone, individuals may find it beneficial to include l-tryptophan-rich foods in their diet. L-tryptophan, an amino acid known for its calming properties, can help soothe the nervous system and counteract anxiety and depression. Moreover, bodybuilders have reported improved sleep quality and an easier time falling asleep while consuming l-tryptophan-rich foods such as whole milk, turkey, chicken, eggs, steak, and tuna, all of which also serve as excellent sources of high-quality protein to aid in protein synthesis and muscle recovery.
It is important to note that consuming ample carbohydrates alongside l-tryptophan-rich foods is crucial, as carbohydrates deplete other amino acid levels in the bloodstream, allowing for improved l-tryptophan absorption and enhancing its sedative effects.
The combination of l-tryptophan and carbohydrates provides a valid explanation for the phenomenon of post-Thanksgiving meal drowsiness experienced by many individuals after consuming large quantities of turkey and potatoes.
8. Tren Cough
Trenbolone administration is associated with a well-known side effect called “Tren cough,” characterized by fits of dry coughing, chest tightness, and a metallic taste in the mouth. This sensation is reported in approximately 20% of injections and is believed to be linked to Trenbolone’s strong androgenic properties, which can induce vasoconstriction in the bronchial muscular wall upon injection.
While similar coughing may occur with Deca Durabolin or Testosterone injections, it is less common compared to Trenbolone.
9. Virilization in Women
Trenbolone poses a high risk of causing virilization side effects in women due to its potent androgenic nature, leading to symptoms such as clitoral enlargement, jaw hypertrophy, breast shrinkage, and a deepened voice. As a result, Trenbolone is not recommended for women aiming to preserve their feminine characteristics. Alternative steroid options such as Anavar, Primobolan, and Deca Durabolin may be more suitable for women looking to build muscle and burn fat with milder side effects.
Summary
Trenbolone’s side effects can vary among users, with some experiencing more severe adverse effects than others. Overall, Trenbolone is known for its harsh side effects, particularly concerning the heart and potential damage to the HPTA. The severity of these effects depends on the dosage and cycle length, with dosages and cycles beyond the typical range posing additional risks.
It is crucial to avoid stacking Trenbolone with compounds that may worsen cholesterol levels and heart health, such as Anadrol, Dianabol, Superdrol, and Winstrol. Additionally, Trenbolone is typically recommended for advanced bodybuilders who have already developed tolerance to various anabolic steroids. This caution is well-founded, as lab results and medical research indicate the compound’s high toxicity.
REFERENCES
(1) https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC4009746/
(2) https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC3167122/
(3) https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC3167122/
(4) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342114/
(5) https://www.sciencedirect.com/science/article/pii/S0306452218307772
Dr. Grant Fourie, a specialist in male hormones, is based in Cape Town, South Africa. He provides comprehensive treatments for conditions related to low testosterone, such as erectile dysfunction, fatigue, and mood changes. His methods include hormone replacement therapy and other modern treatment options.
Contact me via email or phone to book personal appointment in my clinic: The Village Square, Cape Town - South Africa
